Tue08Mar20164:00 pmLewis Hall 101
Department of Internal Medicine
University of Cincinnati
Mechanical Ablation of Tissue with Focused Ultrasound
Histotripsy is a transcutaneous focused ultrasound therapy that ablates tissue through the mechanical oscillations of microbubbles, or cavitation. Preclinical studies have found histotripsy effective for the treatment of prostate pathologies, cancer, deep vein thrombosis, and congenital heart disease. In this talk, the forms of histotripsy and their ablative mechanisms will be modeled in silico, and image-guidance techniques for mechanical ablation will be discussed. An analytic model will be presented to predict the extent of the treatment zone. This analytic model can be used for treatment planning, and to aid the FDA in the development of regulatory standards for histotripsy. Image-guidance of histotripsy will be demonstrated with a new ultrasound imaging modality called passive cavitation imaging (PCI). Studies in a prostate phantom demonstrate that PCI correlates well with the width of the ablation zone, indicating PCI can be used as a predictive metricfor tissue ablation from histotripsy. Finally, PCI will be used to monitor cavitation when histotripsy is used in combination with a lytic agent to lyse clots in a model of deep vein thrombosis. A significant improvement was observed in the thrombolytic efficacy for the combination treatment over histotripsy alone, suggesting a synergistic effect between histotripsy and the lytic agent.