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Department of Physics and Astronomy

University of Mississippi

Dr. Charles Church


Photo of Dr. Church

Office: 1047 NCPA
Phone: (662) 915-6517

Degrees Earned

  • Ph.D., 1983, University of Rochester
  • M.S., 1978, University of Rochester
  • B.S., 1975, Westminster College


  • Postdoctoral Fellow, University of Rochester, 1983-1986
  • Instructor, University of Rochester, 1987-1988
  • Staff Scientist, National Center for Physical Acoustics, 1988-1991
  • Research Scientist, Molecular Biosystems, Inc., 1992-1995
  • Principal Scientist, Acusphere, Inc., 1995-2002
  • Senior Research Scientist, National Center for Physical Acoustics, 2002- present
  • Associate Research Professor, University of Mississippi, 2002- present


  • Acoustical Society of America
  • American Association for the Advancement of Science
  • American Institute of Ultrasound in Medicine
  • Institute of Electrical and Electronics Engineers
  • Sigma Pi Sigma

Research Interests

My primary research interests lie in the general area of biomedical acoustics. Among the specific
topics that we are currently investigating are:
1. the use of high intensity focused ultrasound (HIFU) to reduce or stop clinically significant
hemorrhage from individual blood vessels and solid organs;
2. the use of controlled fields of cavitation bubbles to improve HIFU therapy for solid tumors;
3. the physical responses and biophysical effects of ultrasound contrast agents, i.e.,
microbubbles/microparticles, during preclinical and clinical diagnostic ultrasound examinations;
4. the effect of acoustic nonlinearity on predictions of temperature rise made using the soft-tissue
thermal index (TIS) vs actual temperatures in tissue phantoms.
This work involves close collaboration with colleagues at Boston University, the University of Rochester
and the University of Washington, as well as several commercial firms.

In the future, our group will join an international group of researchers to develop an engineered system
for image-guided HIFU therapy. The “engineered system” concept involves a multi-disciplinary
integration of science and technology applied to complex problems. The final engineered system will
combine HIFU therapy, ultrasound imaging, cavitation monitoring, and control capabilities in a single,
integrated treatment device.