Tue27Feb20184:00 pmLewis Hall 101
Colloquium: Acoustofluidics - Merging Acoustics and Microfluidics for Biomedical Applications
Tony Jun Huang
Pratt School of Engineering
Acoustofluidics: Merging Acoustics and Microfluidics for Biomedical Applications
The past two decades have witnessed an explosion in lab-on-a-chip research with applications in biology, chemistry, and medicine. The continuous fusion of novel properties of physics into microfluidic environments has enabled the rapid development of this field. Recently, a new lab-on-a-chip frontier has emerged, joining acoustics with microfluidics, termed acoustofluidics. Here we summarize our recent progress in this exciting field and show the depth and breadth of acoustofluidic tools for biomedical applications through many unique examples, from exosome separation to cell-cell communications to 3D bioprinting, from circulating tumor cell isolation and detection to ultra-high-throughput blood cell separation for therapeutics, from high-precision micro-flow cytometry to portable yet powerful fluid manipulation systems. These acoustofluidic technologies are capable of delivering high-precision, high-throughput, and high-efficiency cell/particle/fluid manipulation in a simple, inexpensive, cell-phone-sized device. More importantly, the acoustic power intensity and frequency used in these acoustofluidic devices are in a similar range as those used in ultrasonic imaging, which has proven to be extremely safe for health monitoring during various stages of pregnancy. As a result, these methods are extremely biocompatible; i.e., cells and other biospecimen can maintain their natural states without any adverse effects from the acoustic manipulation process. With these unique advantages, acoustofluidic technologies meet a crucial need for highly accurate and amenable disease diagnosis (e.g., early cancer detection and prenatal health) as well as effective therapy (e.g., transfusion and immunotherapy).