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Department of Physics and Astronomy
University of Mississippi


Event Information:

  • Tue

    Colloquium: Transcranial MR-guided Focused Ultrasound Neuromodulation

    4:00 pmZoom Meeting. See Below.

    Charles F. Caskey
    Department of Radiology & Radiological Sciences
    Vanderbilt University Medical Center

    Transcranial MR-guided Focused Ultrasound Neuromodulation

    Ultrasound has the ability to focus energy to a small point beyond the skull and is being widely explored by researchers as a tool for non-invasive neuromodulation. When combined with magnetic resonance imaging (MRI), focused ultrasound (FUS) can be precisely guided while the effects of FUS can be visualized at the network level using fMRI. In this talk, I will discuss our ongoing work in developing systems to apply image-guided FUS neuromodulation in the MRI environment while imaging functional activity. Specifically, I will cover the development of optical tracking as a method to guide FUS neuromodulation, the creation of transducer arrays for steerable FUS neuromodulation, and the development of MR acoustic radiation
    force imaging methods to visualize the acoustic focus. We have used these methods to modulate the somatosensory network in non-human primates, demonstrating that MRI-guided FUS is capable of exciting precise targets in somatosensory areas 3a/3b, causing downstream activations in off-target brain regions within the circuit which we can simultaneously detect with fMRI. Our observations are consistent with others' work in the field of FUS neuromodulation; however, questions remain about mechanisms underlying FUS neuromodulation and potential confounds. The talk will conclude by reporting on recent work at the cellular level where we are measuring calcium signaling in mouse brain slices with optical markers during FUS neuromodulation

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    Meeting ID: 213 798 950