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Department of Physics and Astronomy
University of Mississippi


Event Information:

  • Tue

    Oxford Science Cafe

    6:00 pmVia Zoom (connection details will follow!)

    Dr. Joshua Sharp
    School of Pharmacy
    University of Mississippi

    COVID-19 and Heparan Sulfate: The Carbohydrate Handle that SARS-CoV-2 Uses to Grab Your Cells

    COVID-19, the disease caused by the SARS-CoV-2 virus, has killed over 200,000 Americans in 2020 and changed the way we live our lives. An incredible effort from the scientific community has allowed us to learn a lot about the virus in a very short time. While there are many questions remaining about the disease, we have enough evidence to start answering some important questions. Where do COVID-19 infections usually start in the body? How does SARS-CoV-2 find and enter the target cells? Here, we’ll discuss what we know (and think we know) about how COVID-19 infections get established. We’ll also discuss the discovery and initial development of intranasal heparin, a well-known anti-coagulant injectable that is now in early clinical trials as an intranasal drug to prevent COVID-19. We’ll discuss how heparin works to prevent SARS-CoV-2 infection of cells, why it should be safe to administer intranasally, and why it might NOT be useful as a treatment of advanced COVID-19.

    November 17, 2020, 6:00 - 7:00 PM
    Via Zoom (connection details will follow!)